RESPImmun Publications

Full papers/articles (Journals):

2025

Schindlmaier K, Haitzmann T, Bubalo V, Konrad B, Jelwan J, Bluemel G, Rittchen S, Jäger V, Dengler MA, Brcic L, Lindenmann J, Marsh LM, Eichmann TO, Kirchmair A, Trajanoski Z, Kargl J, Muñoz-Pinedo C, Leithner K: Metabolic adaptation of glucose-deprived macrophages involves partial gluconeogenesis. Proc Natl Acad Sci USA, 2025; 122(44):e2419568122.

Myronenko O, Curcic P, Douschan P, Zeder K, John T, Suessner S, Hoetzenecker K, Kovacs G, Olschewski A, Olschewski H, Foris V: Soluble Transferrin Receptor-1 in Pulmonary Hypertension Associated with COPD. Lung, 2025; 203(1):79.

Rajesh R, Mooslechner A, Schweighofer H, Pahernik S, Lanz I, Atallah R, Platzer W, Aigner C, Benazzo A, Angiari S, Marsh L, Kwapiszewska G, Heinemann A, Bärnthaler T: Succinate aggravates pulmonary fibrosis through the succinate/SUCNR1 axis. Am J Physiol Lung Cell Mol Physiol, 2025; 328(5):L671–L684.

2024

Akhmetshina A, Schooltink L, Amor M, Kuentzel KB, Rainer S, Nandy A, Habisch H, Madl T, Rendina-Ruedy E, Leithner K, Vujić N, Kratky D: Loss or inhibition of lysosomal acid lipase in vitro leads to cholesteryl ester accumulation without affecting muscle formation or mitochondrial function. BBA Adv, 2024; 7:100135.

Demicco M, Liu XZ, Leithner K, Fendt SM: Metabolic heterogeneity in cancer. Nat Metab, 2024; 6(1):18–38.

Teppan J, Schwanzer J, Rittchen S, Bärnthaler T, Lindemann J, Nayak B, Reiter B, Luschnig P, Farzi A, Heinemann A, Sturm E: The disrupted molecular circadian clock of monocytes and macrophages in allergic inflammation. Front Immunol, 2024; 15:1408772.

Csáki R, Nagaraj C, Almássy J, Khozeimeh MA, Jeremic D, Olschewski H, Dobolyi A, Hoetzenecker K, Olschewski A, Enyedi P, Lengyel M: The TREK-1 potassium channel is a potential pharmacological target for vasorelaxation in pulmonary hypertension. Br J Pharmacol, 2024; 181(19):3576–3593.

Atallah R, Gindlhuber J, Platzer W, Rajesh R, Heinemann A: Succinate Regulates Endothelial Mitochondrial Function and Barrier Integrity. Antioxidants (Basel), 2024; 13(12):1579.

Rani A, Stadler JT, Marsche G: HDL and SARS CoV-2: emerging theragnostic implications. Trends Mol Med, 2024; 30(5):425–428.

Rani A, Stadler JT, Marsche G: HDL-based therapeutics: A promising frontier in combating viral and bacterial infections. Pharmacol Ther, 2024; 260:108684.

Haitzmann T, Schindlmaier K, Frech T, Mondal A, Bubalo V, Konrad B, Bluemel G, Stiegler P, Lackner S, Hrzenjak A, Eichmann T, Köfeler HC, Leithner K: Serine synthesis and catabolism in starved lung cancer and primary bronchial epithelial cells. Cancer Metab, 2024; 12(1):9.

Mutgan AC, Radic N, Valzano F, Crnkovic S, El-Merhie N, Evermann M, Hoetzenecker K, Foris V, Brcic L, Marsh LM, Tran-Lundmark K, Jandl K, Kwapiszewska G: A comprehensive map of proteoglycan expression and deposition in the pulmonary arterial wall in health and pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol, 2024; 327(2):L173–L188.

Neumann CJ, Mohammadzadeh R, Woh PY, Kobal T, Pausan M-R, Shinde T, Haid V, Mertelj P, Weiss E-C, Kolovetsiou-Kreiner V, Mahnert A, Kumpitsch C, Jantscher-Krenn E, Moissl-Eichinger C: First-year dynamics of the anaerobic microbiome and archaeome in infants' oral and gastrointestinal systems. mSystems, 2025; 10(1):e0107124.

2023

Vámos E, Kálmán N, Sturm EM, Nayak BB, Teppan J, Vántus VB, Kovács D, Makszin L, Loránd T, Gallyas F Jr, Radnai B: Highly Selective MIF Ketonase Inhibitor KRP-6 Diminishes M1 Macrophage Polarization and Metabolic Reprogramming. Antioxidants (Basel), 2023; 12(10):1790.

Lang M, Krump C, Meshcheryakova A, Tam-Amersdorfer C, Schwarzenberger E, Passegger C, Connolly S, Mechtcheriakova D, Strobl H: Microenvironmental and cell intrinsic factors governing human cDC2 differentiation and monocyte reprogramming. Front Immunol;, 2023; 14:1216352.

Cosic-Mujkanovic N, Valadez-Cosmes P, Maitz K, Lueger A, Mihalic ZN, Runtsch MC, Kienzl M, Davies MJ, Chuang CY, Heinemann A, Schicho R, Marsche G, Kargl J: Myeloperoxidase Alters Lung Cancer Cell Function to Benefit Their Survival. Antioxidants (Basel), 2023; 12(8):1587.

Mihalic ZN, Kloimböck T, Cosic-Mujkanovic N, Valadez-Cosmes P, Maitz K, Kindler O, Wadsack C, Heinemann A, Marsche G, Gauster M, Pollheimer J, Kargl J: Myeloperoxidase enhances the migration and invasion of human choriocarcinoma JEG-3 cells. Redox Biol, 2023; 67:102885.

Stadler JT, Habisch H, Prüller F, Mangge H, Bärnthaler T, Kargl J, Pammer A, Holzer M, Meissl S, Rani A, Madl T, Marsche G: HDL-Related Parameters and COVID-19 Mortality: The Importance of HDL Function. Antioxidants (Basel), 2023; 12(11):2009.

Jandl K, Radic N, Zeder K, Kovacs G, Kwapiszewska G: Pulmonary vascular fibrosis in pulmonary hypertension – The role of the extracellular matrix as a therapeutic target. Pharmacol Ther, 2023; 247:108438.

Mutgan AC, Jandl K, Radic N, Valzano F, Kolb D, Hoffmann J, Foris V, Wilhelm J, Boehm PM, Hoetzenecker K, Olschewski A, Olschewski H, Heinemann A, Wygrecka M, Marsh LM, Kwapiszewska G: Pentastatin, a matrikine of the collagen IVαα5, is a novel endogenous mediator of pulmonary endothelial dysfunction. Am J Physiol Cell Physiol, 2023; 325(5):C1294–C1312.

Rani A, Marsche G: A Current Update on the Role of HDL-Based Nanomedicine in Targeting Macrophages in Cardiovascular Disease. Pharmaceutics, 2023; 15(5):1504.

Rajesh R, Atallah R, Bärnthaler T: Dysregulation of metabolic pathways in pulmonary fibrosis. Pharmacol Therv, 2023; 246:108436.

Myronenko O, Foris V, Crnkovic S, Olschewski A, Rocha S, Nicolls MR, Olschewski H: Endotyping COPD: hypoxia-inducible factor-2 as a molecular "switch" between the vascular and airway phenotypes? Eur Respir Rev, 2023; 32(167):220173.

2022

Stadler JT, Mangge H, Rani A, Curcic P, Herrmann M, Prüller F, Marsche G: Low HDL Cholesterol Efflux Capacity Indicates a Fatal Course of COVID-19. Antioxidants, 2022; 11(10):1858.

Sinha M, Zabini D, Guntur D, Nagaraj C, Enyedi P, Olschewski H, Kuebler WM, Olschewski A: Chloride channels in the lung: Challenges and perspectives for viral infections, pulmonary arterial hypertension, and cystic fibrosis. Pharmacol Ther, 2022; 237:108249.

2021

Bluemel G, Planque M, Madreiter-Sokolowski CT, Haitzmann T, Hrzenjak A, Graier WF, Fendt SM, Olschewski H, Leithner K: PCK2 opposes mitochondrial respiration and maintains the redox balance in starved lung cancer cells. Free Radic Biol Med, 2021; 176:34–45.

Lesko J, Triebl A, Stacher-Priehse E, Fink-Neuböck N, Lindenmann J, Smolle-Jüttner FM, Köfeler HC, Hrzenjak A, Olschewski H, Leithner K: Phospholipid dynamics in ex vivo lung cancer and normal lung explants. Exp Mol Med, 2021; 53(1):81–90.

2020

Smolle E, Leko P, Stacher-Priehse E, Brcic L, El-Heliebi A, Hofmann L, Quehenberger F, Hrzenjak A, Popper HH, Olschewski H, Leithner K: Distribution and prognostic significance of gluconeogenesis and glycolysis in lung cancer. Mol Oncol, 2020; 14(1):2853–2867.